Hollywood icon Jamie Lee Curtis, former Irish rugby captain Brian O'Driscoll and The 2 Johnnies have been confirmed as some of the guests set to appear on this week's Late Late Show.
Curtis - well-known for her performances in blockbusters such as 'Knives Out', 'Everything Everywhere All at Once' and 'Blue Steel' - will speak to Tubridy about her upcoming film 'Halloween Ends' and how she feels about being part of one of the most revered horror franchises in film history.
Curtis will also chat about being the officiant for her daughter's wedding, and why it is important to be an advocate for inclusively.
Author, comedian and presenter Graham Norton will also catch up with Ryan, speaking about everything from his love of West Cork, to life as a novelist, and his brand-new book Forever Home.
O'Driscoll will discuss when, as an elite athlete, the time comes to retire and what comes next - the question he poses in a new documentary with psychologist and RTÉ Sport presenter Richie Sadlier.
Podcast hosts The 2 Johnnies, fresh from selling out Dublin's 3 Arena, will also be on the couch, recounting their most recent adventure in America for a new television production, Johnny B's viral 'catfish' experience, and their RTÉ 2FM radio show.
Founding member of the 221+ CervicalCheck patient support group Stephen Teap and campaigner Lorraine Walsh will speak about the Vicky Phelan ahead of a new documentary, 'Vicky', which is set to be released in cinemas next weekend.
Finally, Ella Henderson and Cian Ducrot will provide the musical entertainment for the evening.
The Late Late Show airs each week on Friday at 9.35pm on RTÉ One.