A 16-year-old student Transition year student of the school, named locally as Kimberly O'Connor, died in the accident, just a short distance from her home, after 11pm last night.
School principal Phil O'Flynn said in a statement this afternoon that two boys injured in the crash also had links to the school.
She said: "I am deeply saddened to report the death of one of our female students and the injury of two other boys, one a current student and the other a past pupil, as the result of a road traffic accident last night. This is a terrible tragedy for the families of the students, our school and our community. Our sympathies and thoughts are with the families and friends of the deceased and injured."
The school's Critical Incident Management Plan has been implemented, she said.
The school was on mid-term break but has reopened today to provide support to its students, as well as parents and the wider community. She said staff and counsellors are on site.
THE teenager killed in last night's horror crash in Knocknaheeny was a transition year student who had recently returned from a trip abroad.
The 16-year-old died in a single vehicle fatal road traffic collision on Harbour View Road, Knocknaheeny late last night.
The car was in collision with a wall.
She was one of four siblings, and was from the Knocknaheeny area. Her family is well known locally.
Another teenager in the car, a boy, was seriously injured and was critically ill in hospital this morning, while another teenage boy received less serious injuries.
It is understood the girl and one of the boys were students of Terence McSwiney College in Knocknaheeny and were off on mid-term this week.
Local representatives have said the whole community is is shock at the news that a teenage girl died overnight on the northside of the city.
The girl was pronounced dead at the scene after a single vehicle fatal road traffic collision in Knocknaheeny late last night.
The car collided with a wall on Harbour View Road.
Two teenage boys who were in the car were also brought to hospital with serious injuries and one of them is in a critical condition.
“Very sad to hear the news of the death of a young girl in a car accident in Harbour View Road,” Local TD Thomas Gould said. “I hope the two young men who were injured will make a recovery. My thoughts and prayers are with the families.
“No words can express the grief especially for the loss of someone so young.”
Councillor Tony Fitzgerald added: “The family and community are in mourning this morning in Knocknaheeny. There is a huge sense of loss. Our thoughts and prayers are with the girls’ family.
“Prayers were said this morning at St Mary’s on the Hill Church for the bereaved and for the recovery of the other two people who were in the car.
“People are shocked and very sad at the loss of life, but we are coming together to support the bereaved."
Meanwhile, Councillor Ken O’Flynn echoed Mr Fitzgerald’s comments saying: “It’s a terrible tragedy. The community on the northside is shocked.
“Everyone is in a state of shock and sadness and my sympathies are with the families involved.”
Gardaí are investigating and the road will remain closed for several more hours. The body of the girl has been brought to CUH where a post mortem will take place.
A teenage girl is dead and two teenage boys are in hospital following a single vehicle fatal road traffic collision on Harbour View Road, Knocknaheeny late last night.
The car collided with a wall on Harbour View Road.
Emergency services and the Roads Policing Unit attended the scene.
"A female youth, aged in her teens, who was a passenger in the car was pronounced dead at the scene," a Garda spokesperson said. "The driver and a second passenger, males in their teens, received serious injuries. Both were taken to Cork University Hospital for treatment.
"The male passenger’s condition is believed to be critical."
The body of the teenage girl was removed to the mortuary at Cork University Hospital where a post mortem will be carried out.
The Harbour View Road is partially closed for Garda Forensic Collision Investigators with local diversions in place. It is expected to remain closed until lunchtime.
Gardaí are appealing to anyone who may have information regarding the collision, particularly any road users with camera footage who were travelling Harbour View Road between 11pm and 12.30am, to contact Gurranabraher Garda Station on 021 494 6200, the Garda Confidential Line on 1800 666 111 or any Garda Station.
This is the third death on Cork roads this week.
On Monday, a man in his forties was killed on the N27, main Cork to Kinsale Road while a man in his 50s died in a crash on the N20 Cork to Limerick Rd late on Tuesday night.
Harbour View Rd in Hollyhill is closed following a serious road traffic incident overnight and is expected to remain closed for several more hours.
Gardaí in Anglesea Street are investigating an incident which took place shortly before midnight and a spokesperson told The Echo they expect the road to remain closed until at least lunchtime on Thursday.
The road is closed near the library next to Courtown Drive following a collision.
Emergency services were called to the scene late on Wednesday night. Three units of the fire service were in attendance, one from Ballyvolane and two from Anglesea.
More to follow.