Jack Conan was named man of the match as Leinster got the job done against Ulster winning by 30-15 in the last-16 tie in Heineken Champions Cup.
Earlier Munster's campaign came to an end in the heat in Durban after a 50-35 defeat by Sharks in their last-16 tie at King's Park.
Meanwhile, Connacht are out of the Challenge Cup after a 41-19 defeat to Benetton in Italy.
In the Women's Six Nations, it was another tough day the office for Ireland losing to France by 53-3 at Musgrave Park.
Arsenal eased to a 4-1 victory over Leeds United to restore their eight point lead over Manchester City at the top of the Premier League. Striker Gabriel Jesus got a brace.
Meanwhile, second-placed Manchester City were 4-1 winners against Liverpool.
Brighton fought from behind to earn a 3-3 draw with fellow European qualification chasers Brentford.
Bournemouth moved out of the relegation places with a 2-1 success over Fulham.
Roy Hodgson's first game back as Crystal Palace boss ended in a 2-1 victory over Leicester.
Nottingham Forest drew 1-1 with fellow strugglers Wolves.
In the late game, Aston Villa beat Chelsea 2-0 at Stamford Bridge.
League of Ireland
There's one game in the League of Ireland Premier Division.
Bohemians will return to the top of the table if they avoid defeat away to Sligo Rovers at 8.15pm.
Sligo have beaten Wicklow by 2-10 to 14 points at Croke Park to the clinch the AFL Divsion 4 title.
Cavan lead Fermanagh by 3 points to 2, in the Division 3 decider.
Roscommon confortably beat Armagh by 2-17 to 0-15 in the Allianz Hurling League Division 3A final in Navan.
Cavan just edged it 0-17 to 0-16 in the Division 3B final.