The bulk of Munster's playing and backroom staff are on their way back from South Africa.
The Irish provincial team are set to travel home after being stranded in Cape Town following the cancellation of their scheduled cross-hemisphere matches in the United Rugby Championship due to the discovery of a new coronavirus variant.
Fresh travel restrictions were imposed on South Africa and Munster and Cardiff had hoped to join the Scarlets and Zebre Parma in leaving on Sunday aboard a charter flight before positive cases caused a hold-up.
Despite announcing on Tuesday night that a further four members of the touring party had tested positive - adding to the 10 already confirmed - Munster said 34 players and staff left Cape Town after receiving negative results from a fourth round of PCR testing in six days.
The announcement came after Cardiff revealed plans to travel to quarantine accommodation in England on Thursday. Munster personnel will isolate at home on their return to Ireland.
A Munster statement read: "Team management worked tirelessly on securing scheduled flights at short notice and the group are expected to land in Dublin on Wednesday evening.
"Another four positive cases were identified in Tuesday's round of PCR testing and a total group of 14 will see out their respective isolation periods at the designated quarantine hotel in Cape Town.
"The group will be well looked after, with team liaisons Warren Morris and Kubaan Lorens remaining on site with medical support provided daily.
"As outlined by the government earlier this week, on arrival from South Africa the returning players and staff will follow mandatory self-isolation at their own locations.
"Again, we wish to take this opportunity to thank the Irish government, the IRFU, South Africa Rugby, UR, and the health authorities for their assistance, in particular with regards to facilitating the safe return of our staff and players."