ANDREW Conway replaces Munster team-mate Keith Earls on the wing after Earls was ruled out of Sunday’s World Cup opener against Scotland in Yokohama, 8.45am Irish time.
Rob Kearney is another injury casualty and he is replaced by Leinster team-mate Jordan Larmour.
Conway comes in for his 16th cap, which is one less than Larmour.
"It was just that we were getting very tight for time, the best continuity we had was we felt was to have the guys who trained through the time that we've been here, it's exciting to have the back three that we have," head coach Joe Schmidt said ahead of the game.
Chris Farrell has to be content with a place on the bench after Schmidt put Garry Ringrose and Bundee Aki in the centre.
Schmidt also retains Rory Best as his hooker with Cork’s Niall Scannell on the bench.
The coach can rest easier with the experience he has in his back-row where he has opted for Peter O’Mahony, Josh van der Flier, and CJ Stander, while Iain Henderson partners James Ryan in the second row.
The halfback pairing is made up of Conor Murray and Johnny Sexton and their experience could be crucial in Sunday’s game.
Tadhg Beirne and Jack Conan will give plenty of speed and power up front when they come as they are named on the bench while Jack Carty is included as Munster 10 Joey Carbery is given another week to get his ankle injury fully healed for the clash with the host nation on Saturday week.
IRELAND: J Larmour; A Conway, G Ringrose, B Aki, J Stockdale; J Sexton, C Murray; C Healy, R Best (c), T Furlong; J Ryan, I Henderson; P O’Mahony, K van der Flier, CJ Stander.
Replacements: N Scannell, D Kilcoyne, A Porter, T Beirne, J Conan, L McGrath, Jack Carty, Chris Farrell