Road diversions are in place on the main thoroughfare through Macroom as emergency services deal with a blaze at a premises in the town.
The premises is near the Macroom bridge.
Traffic is being diverted via the Mill Road.
AA Roadwatch has said the incident is causing some disruption: "The N22 is closed in Macroom at Castle St as emergency services deal with a fire. Gardaí are diverting traffic."
Two fire units from Macroom and Ballincollig Fire Station are currently working on the property which caught fire on Sunday evening.
Emergency services rushed to the scene which is located near the Macroom bridge at 6.10pm and 6.32pm respectively after the emergency call was received from a security company at 6.04pm this evening.
It is understood a significant amount of smoke damage has been done to the property.