The incident happened at Smith Street, a narrow road between Oliver Plunkett Street and South Mall.
Gardaí are appealing for witnesses and anyone who may have dash cam footage.
A statement from the Garda Press Office this morning said: "Gardaí are investigating a fatal road traffic collision involving a truck and a pedestrian that occurred in the Smith Street area of Cork City on 10/02/2020 at approximately 3:50pm.
"A female pedestrian, aged in her 50s, was taken to Cork University Hospital by ambulance where she was later pronounced dead. A technical examination of the scene has been carried out.
"Gardaí are appealing for anyone with information, particularly any road users who may have dash cam footage of the area from the time of the collision, to contact Gardaí at Anglesea Street on 021 452 2000 or the Garda Confidential Line on 1800 666 111."