The Department of Health has confirmed the death of a further 28 patients diagnosed with Covid-19 and a further 500 new cases.
There have now been 263 Covid-19 related deaths in the Republic and the total number of confirmed cases stands at 6,574.
22 of the 28 people who died were in the east of the country, two were located in the north west, two in the south, and two in the west of the country.
The Covid-19 related deaths include 15 females and 13 males. 19 people were reported as having underlying health conditions.
There were also four more deaths recorded in the North, bringing the total number of deaths on the island of Ireland to 345.
Data released yesterday, covering cases recorded up until midnight on Tuesday, revealed that Cork has the second-highest number of confirmed cases at 472, 7% of all cases.
Dublin has the highest number of cases at 3,557, 55% of all cases..
45% of confirmed cases are male and 53% are female, with 317 clusters involving 1,391 cases. The median age of confirmed cases is 48 years.
A total of 1,521 cases have been hospitalised. Of those hospitalised, 230 cases have been admitted to ICU. 1,765 cases are associated with healthcare workers.
Of those for whom transmission status is known, community transmission accounts for 66%, close contact accounts for 24%, travel abroad accounts for 9% The National Public Health Emergency Team’s modelling data has revealed that Ireland’s effort to date has greatly reduced the transmission of the virus.
The growth rate has reduced from 33% daily in the early weeks of this outbreak, to 9% this week.
Dr Tony Holohan said: “The virus is still sustaining itself in our community. If we do not stay at home and practice physical distancing then we are not stopping the spread.
“It is crucial that each one of us take seriously the risks this virus poses, follow the guidelines and limit the opportunity for this virus to spread.
“We must follow the public health advice as closely as we possibly can so that we can limit the spread of the virus.
"Stay at home, practice physical distancing, practice hand hygiene, protect each other."
Earlier today, Minister for Health Simon Harris said restrictions on public movement currently in place are “not going to be lifted tomorrow”.
New regulations signed by Minister for Health Simon Harris on Tuesday will see those found disregarding the 2km radius travel restrictions fined or imprisoned.
Those caught travelling without an essential reason or those exercising more than 2km from their homes can be given a fine of up to €2,500 or a prison sentence of up to six months.
Garda Commissioner Drew Harris also announced on Wednesday that people staying in their holiday homes will need to remain there for the duration of the Covid-19 restrictions.