The Department of Health has confirmed the death of a further 43 patients diagnosed with Covid-19 bringing the total number of deaths to 486.
It is the highest number of deaths recorded on a single day in the Republic since the outbreak of the virus.
A further 629 new cases of Covid-19 have been confirmed.
A further 95 cases of coronavirus have been confirmed from the backlog of tests at the laboratory in Germany, bringing the total number of additional cases to 724.
The total number of Covid-19 cases in Ireland is now 13,271.
34 people who died were in the east of the country, four in the west and five in the south of the country.
The Covid-19 related deaths include 22 males and 21 females. 27 people were reported as having underlying health conditions.
Data released today, covering cases recorded up until midnight on Tuesday, revealed that Cork has the second-highest number of confirmed cases at 916, 7% of all cases.
Dublin has the highest number of cases with 6,337, 51% of all cases..
45% of confirmed cases are male and 55% are female, with 425 clusters involving 2,451 cases. The median age of confirmed cases is 48 years.
A total of 2,026 people with Covid-19 have been hospitalised. Of those hospitalised, 284 have been admitted to ICU. 3,090 cases are associated with healthcare workers.
Of those for whom transmission status is known, community transmission accounts for 51%, close contact accounts for 43%, travel abroad accounts for 6%.
Chief Medical Officer, Dr Tony Holohan, said that current restrictions are suppressing the spread of the virus.
“The data clearly shows that there are two very different experiences of Covid-19 in Ireland today. In the population at large, the virus is contained and effectively suppressed.
“However, the experience of the disease in long-term residential care settings continues to be a source of concern.
“In order to protect the vulnerable the first task was to suppress the virus in the population at large. We are increasingly confident that we are achieving this. All of our efforts now need to be on extinguishing Covid-19 in our community residential settings, including nursing homes.” Speaking in the Dáil earlier today, Minister for Health Simon Harris said nursing home residents must take priority during the pandemic.
"They are citizens of this country.
"Nursing homes are our priority, and we need to take serious action, no doubt this is a virus that doesn't discriminate but has an impact on older people.
"91% of deaths have been people over 65, and two-thirds had underlying health conditions, and this virus is having a devastating impact on the nursing home sector.
"There is a huge amount of work underway, we have 18 Covid-19 response teams going into nursing homes, 61 of our own HSE staff in nursing homes, and that number is expected to grow.
He also said that a serious conversation was needed about the care of elderly people after the pandemic.
"We need to have a serious conversation about how we care for older people in this country after this pandemic, the current model is not fit for purpose,” he said.