Tánaiste Leo Varadkar is restricting his movements for the coming days after testing negative for Covid-19.
It comes after he was notified that someone he had come in contact with had tested positive.
He was swabbed for the virus yesterday.
A statement from the Tánaiste states: “Yesterday I was informed that I was a close contact of someone who tested positive for Covid-19.
"I was swabbed yesterday and the test has come back negative.
“In line with public health advice, I will be restricting my movements to home and outdoor exercise.
"There are no implications for anyone who has been in close contact with me. I am perfectly well and will be working from home.”
It comes following confirmation that Finance Minister Paschal Donohoe is also restricting his movements after close contact with a confirmed case of Covid-19.
The Minister's French counterpart Bruno Le Maire tested positive for the virus following a Eurogroup meeting in Germany on September 11th, which Minister Donohoe attended in his role as president of the group.
Mr Donohoe will remain away from in-person contact in his Government role until Saturday.
Last week, Health Minister Stephen Donnelly temporarily isolated himself pending a negative test for Covid-19 after he began feeling unwell.
The incident saw Cabinet ministers temporarily restrict their movements alongside Mr Donnelly as his close contacts.